Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.37 |
| ▸ | CDC42BPB | Q9Y5S2 | 2/20 | 0.37 |
| ▸ | CCNK | O75909 | 1/20 | 0.36 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.36 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 5/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.32 |
| ▸ | KHK | P50053 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.30 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.30 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.30 |
| ▸ | PLK4 | O00444 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2600508 | 0.79 | ROCK2 (0.39) | ROCK2ROCK1CDC42BPBCCNKCDK12 | |
| SCHEMBL1565524 | 0.78 | CCNK (0.35) | ROCK2ROCK1CDC42BPBCCNKCDK12 | |
| SCHEMBL2600506 | 0.76 | AXL (0.50) | ROCK2ROCK1CDC42BPBCCNKCDK12 | |
| SCHEMBL2600520 | 0.76 | AKT1 (0.38) | ROCK2ROCK1CDC42BPBCCNKCDK12 | |
| SCHEMBL24682764 | 0.76 | TRPA1 (0.38) | ROCK2ROCK1CDC42BPBCCNKCDK12 | |
| SCHEMBL2600518 | 0.72 | ROCK2 (0.35) | ROCK2ROCK1CDC42BPBCCNKCDK12 | |
| SCHEMBL21632480 | 0.72 | MAPK1 (0.36) | ROCK2ROCK1CDC42BPBCDC42BPAMAPK1 | |
| SCHEMBL2600517 | 0.72 | ROCK2 (0.35) | ROCK2ROCK1CDC42BPBCCNKCDK12 | |
| SCHEMBL2600519 | 0.72 | ROCK2 (0.35) | ROCK2ROCK1CDC42BPBCCNKCDK12 | |
| SCHEMBL2600504 | 0.72 | LRRK2 (0.39) | ROCK2ROCK1CDC42BPBCCNKCDK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158647-B2 | Substituted pyrrolopyridines and pyrazolopyridines as kinase modulators | SGX PHARMACEUTICALS, INC. (US) | 2012-04-17 | — | — | US | disclosed |
| US-20090005356-A1 | SUBSTITUTED PYRROLOPYRIDINES AND PYRAZOLOPYRIDINES AS KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2009-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005356-A1 | SUBSTITUTED PYRROLOPYRIDINES AND PYRAZOLOPYRIDINES AS KINASE MODULATORS | PDXK, MAP3K4, PDPK1 | ROCK2 817/4885ROCK1 678/4885CDC42BPB 264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.