Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 3/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18183184 | 0.82 | SYK (0.36) | MAPTGAATDP1JAK1ALDH1A1 | |
| SCHEMBL5965015 | 0.81 | HTT (0.37) | PDK2MAPTGAATDP1ALDH1A1 | |
| SCHEMBL26005634 | 0.80 | CCNC (0.44) | CCNCCDK8PDK2GAAJAK3 | |
| SCHEMBL31255464 | 0.78 | ALDH1A1 (0.44) | GAAJAK3JAK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL10084730 | 0.77 | ALPI (0.51) | CCNCCDK8PDK2MAPTGAA | |
| SCHEMBL17094936 | 0.77 | MEN1 (0.46) | MAPTGAAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL23011679 | 0.76 | CCNC (0.43) | CCNCCDK8PDK2MAPTMAP4K4 | |
| SCHEMBL17207643 | 0.76 | TAS2R8 (0.44) | CCNCCDK8PDK2MAPTMAP4K4 | |
| SCHEMBL17605717 | 0.76 | ALDH1A1 (0.47) | CCNCCDK8PDK2MAPTGAA | |
| SCHEMBL17382262 | 0.76 | CCNC (0.43) | CCNCCDK8PDK2MAPTMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154314-A1 | SPIRO PIPERIDINE DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |