Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.39 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30623400 | 0.90 | CCR2 (0.43) | HTR2CHTR2AHTR2BSIGMAR1 | |
| SCHEMBL25356724 | 0.90 | CCR2 (0.43) | HTR2CHTR2AHTR2BSIGMAR1 | |
| SCHEMBL11668352 | 0.81 | SIGMAR1 (0.40) | HTR2CHTR2AHTR2BCYP3A4TSHR | |
| SCHEMBL26008714 | 0.81 | KDM1A (0.40) | HTR2AOPRM1OGFRL1SIGMAR1ALDH1A1 | |
| SCHEMBL25359962 | 0.78 | HTR2C (0.46) | HTR2CHTR2AHTR2BSIGMAR1 | |
| SCHEMBL4977596 | 0.78 | KDM1A (0.40) | HTR2CHTR2AHTR2BOPRM1OPRL1 | |
| SCHEMBL30484433 | 0.75 | SIGMAR1 (0.55) | HTR2CHTR2AOPRM1SIGMAR1 | |
| SCHEMBL1588897 | 0.75 | SIGMAR1 (0.55) | HTR2CHTR2AOPRM1SIGMAR1 | |
| SCHEMBL25360353 | 0.74 | HTR2C (0.40) | HTR2CHTR2AHTR2BTSHRSIGMAR1 | |
| SCHEMBL8766446 | 0.74 | KDM1A (0.49) | CYP3A4TSHRSIGMAR1ALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154314-A1 | SPIRO PIPERIDINE DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |