Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SDCBP | O00560 | 6/20 | 0.40 |
| ▸ | SDC2 | P34741 | 6/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25993223 | 0.85 | THRB (0.33) | THRBGAASDCBPSDC2POLB | |
| SCHEMBL25986037 | 0.84 | THRB (0.33) | THRBGAASDCBPSDC2POLB | |
| SCHEMBL25993979 | 0.80 | PRMT5 (0.33) | SDCBPSDC2POLBNAMPT | |
| SCHEMBL25982147 | 0.79 | PRMT5 (0.34) | NAMPT | |
| SCHEMBL26004028 | 0.77 | — | — | |
| SCHEMBL24266854 | 0.77 | MAPT (0.40) | THRBGAASDCBPSDC2POLB | |
| SCHEMBL25993259 | 0.76 | THRB (0.33) | THRBGAAPOLBLMNANAMPT | |
| SCHEMBL26020707 | 0.74 | THRB (0.43) | THRBGAASDCBPSDC2POLB | |
| SCHEMBL26024862 | 0.74 | SDCBP (0.42) | THRBGAASDCBPSDC2POLB | |
| SCHEMBL25942761 | 0.73 | THRB (0.40) | THRBGAASDCBPSDC2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3820573-B1 | 3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF IKAROS FAMILY ZINC FINGER 2 (IKZF2)-DEPENDENT DISEASES | NOVARTIS AG (CH) | 2023-08-09 | — | — | EP | disclosed |