Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25985821 | 0.86 | SIGMAR1 (0.30) | — | |
| SCHEMBL27471346 | 0.83 | ADRA1D (0.39) | — | |
| SCHEMBL24590647 | 0.77 | — | — | |
| SCHEMBL27019779 | 0.73 | METAP1 (0.39) | METAP1 | |
| SCHEMBL25992239 | 0.71 | METAP1 (0.41) | METAP1 | |
| SCHEMBL20936104 | 0.68 | — | — | |
| SCHEMBL26022379 | 0.66 | METAP1 (0.33) | METAP1 | |
| SCHEMBL25994241 | 0.66 | METAP1 (0.32) | METAP1 | |
| SCHEMBL26017524 | 0.66 | METAP1 (0.32) | METAP1 | |
| SCHEMBL27124135 | 0.65 | SLC6A2 (0.32) | METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3820573-B1 | 3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF IKAROS FAMILY ZINC FINGER 2 (IKZF2)-DEPENDENT DISEASES | NOVARTIS AG (CH) | 2023-08-09 | — | — | EP | disclosed |