Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 2/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 2/20 | 0.35 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 4/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 3/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27019778 | 0.76 | — | — | |
| SCHEMBL26020171 | 0.73 | METAP1 (0.33) | METAP1 | |
| SCHEMBL25985821 | 0.72 | SIGMAR1 (0.30) | — | |
| SCHEMBL27006161 | 0.71 | MAPT (0.41) | METAP1PRMT5WDR77ADAM17PDE4A | |
| SCHEMBL1074709 | 0.69 | KMT2A (0.48) | METAP1MAOBHTR2AHTR2CHTR2B | |
| SCHEMBL27471346 | 0.68 | ADRA1D (0.39) | — | |
| SCHEMBL17313321 | 0.67 | AOC3 (0.50) | PRMT5WDR77AOC3 | |
| SCHEMBL3655326 | 0.66 | PRMT5 (0.50) | METAP1PRMT5WDR77ADAM17MIF | |
| SCHEMBL6855815 | 0.65 | METAP1 (0.43) | METAP1MIFMAOB | |
| SCHEMBL30021259 | 0.65 | METAP1 (0.50) | METAP1PRMT5WDR77ADAM17MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4306111-A2 | 3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF | Novartis AG (CH) | 2024-01-17 | — | — | EP | disclosed |