Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.38 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21618150 | 0.89 | ALDH1A1 (0.50) | ALDH1A1MAPTHPGDKMT2ALMNA | |
| SCHEMBL31560857 | 0.80 | ALDH1A1 (0.49) | ALDH1A1MAPTHPGDKMT2ALMNA | |
| SCHEMBL7323206 | 0.80 | ALDH1A1 (0.48) | ALDH1A1MAPTHPGDKMT2ALMNA | |
| SCHEMBL28729952 | 0.78 | KMT2A (0.56) | ALDH1A1MAPTHPGDKMT2ALMNA | |
| SCHEMBL15262747 | 0.76 | PPARG (0.43) | ALDH1A1LMNATSHRSMN1; SMN2NOS3 | |
| SCHEMBL17156294 | 0.76 | ALDH1A1 (0.47) | ALDH1A1MAPTHPGDKMT2ALMNA | |
| SCHEMBL27561768 | 0.75 | PPARA (0.43) | HPGDLMNATSHR | |
| SCHEMBL14278560 | 0.74 | ALDH1A1 (0.44) | ALDH1A1MAPTHPGDKMT2AMEN1 | |
| SCHEMBL4015947 | 0.74 | CASP1 (0.47) | ALDH1A1MAPTHPGDKMT2ALMNA | |
| SCHEMBL9423833 | 0.73 | ALDH1A1 (0.47) | ALDH1A1MAPTHPGDKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3820573-B1 | 3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF IKAROS FAMILY ZINC FINGER 2 (IKZF2)-DEPENDENT DISEASES | NOVARTIS AG (CH) | 2023-08-09 | — | — | EP | disclosed |