Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R1 | P27986 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26022701 | 0.80 | HSD11B1 (0.33) | PIK3R1PIK3CAHSD11B1 | |
| SCHEMBL26022751 | 0.72 | PIK3R1 (0.30) | PIK3R1PIK3CA | |
| SCHEMBL26022758 | 0.68 | AR (0.36) | PIK3R1PIK3CA | |
| SCHEMBL26022760 | 0.68 | PIK3R1 (0.34) | PIK3R1PIK3CA | |
| SCHEMBL26022781 | 0.66 | HSD11B1 (0.30) | HSD11B1 | |
| SCHEMBL26022703 | 0.66 | — | — | |
| SCHEMBL26022757 | 0.63 | PIK3R1 (0.33) | PIK3R1PIK3CA | |
| SCHEMBL12574036 | 0.63 | — | — | |
| SCHEMBL7903751 | 0.61 | — | — | |
| SCHEMBL26022761 | 0.60 | HSD11B1 (0.33) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230265096-A1 | APOL1 INHIBITORS AND METHODS OF USE | HERCULES CAPITAL, INC., AS AGENT | 2023-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230265096-A1 | APOL1 INHIBITORS AND METHODS OF USE | APOL1, APOB, LDLR | PIK3R1 4694/4885PIK3CA 4711/4885HSD11B1 304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.