Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 4/20 | 0.44 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | TLR2 | O60603 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25587276 | 0.85 | CA1 (0.40) | TAS1R3TAS1R1TAS1R2CA1CA2 | |
| SCHEMBL25587273 | 0.85 | CA1 (0.40) | TAS1R3TAS1R1TAS1R2CA1CA2 | |
| SCHEMBL25587274 | 0.85 | CA1 (0.40) | TAS1R3TAS1R1TAS1R2CA1CA2 | |
| SCHEMBL12788565 | 0.83 | CA12 (0.46) | TAS1R3TAS1R1TAS1R2CA1CA2 | |
| SCHEMBL16638817 | 0.78 | CTSK (0.45) | TAS1R3TAS1R1TAS1R2CA1CA2 | |
| SCHEMBL13888611 | 0.78 | TAS1R3 (0.47) | TAS1R3TAS1R1TAS1R2CA1CA2 | |
| SCHEMBL25590147 | 0.78 | TDP1 (0.43) | CA1CA2CA12MMP1MMP2 | |
| SCHEMBL12443569 | 0.78 | TDP1 (0.43) | CA1CA2CA12MMP1MMP2 | |
| SCHEMBL17506705 | 0.78 | TAS1R3 (0.47) | TAS1R3TAS1R1TAS1R2CA1CA2 | |
| SCHEMBL25590146 | 0.78 | TDP1 (0.43) | CA1CA2CA12MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023158795-A1 | INHIBITORS OF RNA HELICASE DHX9 AND USES THEREOF | ACCENT THERAPEUTICS, INC. (US) | 2023-08-24 | — | — | WO | disclosed |
| WO-2023154519-A1 | INHIBITORS OF RNA HELICASE DHX9 AND USES THEREOF | ACCENT THERAPEUTICS, INC. (US) | 2023-08-17 | — | — | WO | disclosed |