Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARG | P13631 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.35 |
| ▸ | GUSB | P08236 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26027642 | 0.88 | TNKS (0.43) | RARGALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL26026549 | 0.87 | RARG (0.46) | RARGCNR2GUSBALDH1A1LMNA | |
| SCHEMBL29620356 | 0.87 | RARG (0.46) | RARGCNR2GUSBALDH1A1LMNA | |
| SCHEMBL26026689 | 0.83 | RARG (0.50) | RARGGUSBALDH1A1LMNAKDM4E | |
| SCHEMBL26027147 | 0.82 | ALDH1A1 (0.39) | RARGGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL29620364 | 0.77 | ALDH1A1 (0.39) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL26027655 | 0.76 | TNKS (0.43) | ALDH1A1SMN1; SMN2KMT2AMEN1AR | |
| SCHEMBL27089947 | 0.74 | PARP1 (0.45) | ALDH1A1SMN1; SMN2KMT2AMEN1PARP1 | |
| SCHEMBL26026865 | 0.73 | RARG (0.44) | RARGLMNAHTTARPARP1 | |
| SCHEMBL26026993 | 0.73 | RARG (0.44) | RARGLMNAHTTARPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154842-A1 | THR BETA ANALOGS AND USES THEREOF | MADRIGAL PHARMACEUTICALS, INC. (US) | 2023-08-17 | — | — | WO | disclosed |