Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.52 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 3/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.51 |
| ▸ | BRAF | P15056 | 10/20 | 0.50 |
| ▸ | RAF1 | P04049 | 9/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | HPGDS | O60760 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26033639 | 0.95 | MAPK14 (0.52) | RIPK1RIPK3LCKMAPK14BRAF | |
| SCHEMBL2619542 | 0.90 | HPGDS (0.50) | RIPK1RIPK3LCKMAPK14BRAF | |
| SCHEMBL1017093 | 0.90 | MTOR (0.53) | BRAFCYP1A2CYP3A4TSHRHPGDS | |
| SCHEMBL26033619 | 0.86 | KIF18A (0.51) | RIPK1RIPK3LCKMAPK14BRAF | |
| SCHEMBL2619317 | 0.85 | MAPK14 (0.47) | LCKMAPK14BRAFHPGDSALDH1A1 | |
| SCHEMBL1020175 | 0.85 | MTOR (0.51) | BRAFHPGDSALDH1A1 | |
| SCHEMBL26033240 | 0.85 | HIF1A (0.58) | MAPK14BRAFRAF1HIF1A | |
| SCHEMBL26033613 | 0.83 | HCAR3 (0.51) | RAF1CYP1A2ALDH1A1CYP2C19HIF1A | |
| SCHEMBL26033198 | 0.83 | RAF1 (0.60) | BRAFRAF1CYP1A2CYP2C19 | |
| SCHEMBL26033666 | 0.82 | KIF18A (0.45) | MAPK14BRAFCYP2C19KIF18A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230265054-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2023-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230265054-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | SHH, GLI1, SMO | RIPK1 702/4885RIPK3 527/4885LCK 1002/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.