Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 6/20 | 0.54 |
| ▸ | LCK | P06239 | 5/20 | 0.54 |
| ▸ | KIT | P10721 | 4/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.53 |
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 5/20 | 0.52 |
| ▸ | ABL2 | P42684 | 2/20 | 0.52 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | BCR | P11274 | 2/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | DDX3X | O00571 | 1/20 | 0.48 |
| ▸ | GAK | O14976 | 1/20 | 0.48 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1016677 | 0.91 | LMNA (0.50) | EGFRKDM4EALDH1A1MAPTRAB9A | |
| SCHEMBL12214664 | 0.90 | ALDH1A1 (0.49) | CSF1RLCKKITEGFRKDM4E | |
| SCHEMBL1017567 | 0.81 | BTK (0.58) | CSF1RLCKKITMAPK14EGFR | |
| SCHEMBL2619308 | 0.81 | BTK (0.57) | CSF1RLCKKITMAPK14EGFR | |
| SCHEMBL1016804 | 0.79 | CYP3A4 (0.55) | RAB9AALBCYP3A4ABCG2 | |
| SCHEMBL26033258 | 0.79 | CSF1R (0.54) | CSF1RLCKKITMAPK14EGFR | |
| SCHEMBL12974826 | 0.79 | IKBKE (0.47) | CSF1RLCKKITMAPK14EGFR | |
| SCHEMBL26033294 | 0.79 | ABL1 (0.53) | MAPK14RAB9AABL1 | |
| SCHEMBL26033252 | 0.79 | HDAC1 (0.53) | MAPK14KDRRAB9AABL1RAF1 | |
| SCHEMBL12727164 | 0.79 | RAB9A (0.53) | KDM4EALDH1A1MAPTRAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230265054-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2023-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230265054-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | SHH, GLI1, SMO | CSF1R 256/4885LCK 1002/4885KIT 113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.