Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 13/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 10/20 | 0.41 |
| ▸ | CLK2 | P49760 | 7/20 | 0.41 |
| ▸ | CLK1 | P49759 | 7/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 6/20 | 0.41 |
| ▸ | CLK3 | P49761 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26036527 | 0.87 | MEN1 (0.43) | CLK4DYRK1ACLK2CLK1DYRK1B | |
| SCHEMBL24163604 | 0.74 | FFAR1 (0.43) | CLK4DYRK1ACLK2CLK1DYRK1B | |
| SCHEMBL28233999 | 0.71 | SLC6A2 (0.43) | CLK4DYRK1ACLK2CLK1DYRK1B | |
| SCHEMBL17663978 | 0.70 | TSHR (0.42) | MAPK1ALDH1A1KMT2ASLC6A2SLC6A4 | |
| SCHEMBL25007409 | 0.68 | KDM4E (0.49) | CLK4DYRK1ACLK1MAPK1ALDH1A1 | |
| SCHEMBL7046408 | 0.68 | FABP1 (0.50) | CYP1A2ALDH1A1MEN1KMT2A | |
| SCHEMBL30724679 | 0.68 | DYRK1A (0.53) | CLK4DYRK1ACLK2CLK1DYRK1B | |
| SCHEMBL30854991 | 0.67 | NPC1 (0.51) | ALDH1A1 | |
| SCHEMBL28971693 | 0.65 | CLK4 (0.52) | CLK4DYRK1ACLK2CLK1DYRK1B | |
| SCHEMBL5855082 | 0.65 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230271950-A1 | ANTIBACTERIAL PICOLINAMIDE COMPOUNDS | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2023-08-31 | — | — | US | disclosed |
| US-20230271950-A1 | ANTIBACTERIAL PICOLINAMIDE COMPOUNDS | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2023-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230271950-A1 | ANTIBACTERIAL PICOLINAMIDE COMPOUNDS | RPL35, RPL5, RPL23 | CLK4 2510/4885DYRK1A 1713/4885CLK2 2513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.