Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GBA1 | P04062 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PNMT | P11086 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17663981 | 0.86 | GPR52 (0.38) | MAPK1GBA1KDM5AKDM5BCYP3A4 | |
| SCHEMBL23716473 | 0.86 | CYP3A4 (0.36) | KMT2AATMALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL23716376 | 0.83 | L3MBTL1 (0.36) | IDO1ALDH1A1NPC1KDM4AKDM5A | |
| SCHEMBL28233999 | 0.78 | SLC6A2 (0.43) | TSHRMAPK1KMT2AIDO1ATM | |
| SCHEMBL17664101 | 0.77 | GBA1 (0.53) | TSHRMAPK1KMT2AHSD17B10GBA1 | |
| SCHEMBL5855082 | 0.74 | SLC6A2 (0.45) | ATMCYP2D6KDM4AKDM5AKDM5B | |
| SCHEMBL5742694 | 0.73 | PNMT (0.46) | IDO1ATMALDH1A1NPC1POLB | |
| SCHEMBL5743523 | 0.72 | SLC6A2 (0.42) | TSHRKDM4AKDM5AKDM5BPNMT | |
| SCHEMBL3298586 | 0.71 | IDO1 (0.64) | IDO1ALDH1A1POLBHTTCYP3A4 | |
| SCHEMBL26036525 | 0.70 | CLK4 (0.41) | MAPK1KMT2AALDH1A1SLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3209732-B1 | SPHINGOSINE-1-PHOSPATE RECEPTOR MODULATORS FOR TREATMENT OF CARDIOPULMONARY DISORDERS | SCRIPPS RESEARCH INST (US) | 2021-08-04 | — | — | EP | disclosed |
| WO-2016053855-A1 | SPHINGOSINE-1-PHOSPATE RECEPTOR MODULATORS FOR TREATMENT OF CARDIOPULMONARY DISORDERS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2016-04-07 | — | — | WO | disclosed |