Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 4/20 | 0.34 |
| ▸ | NOS2 | P35228 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | BCR | P11274 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13610891 | 0.78 | MEN1 (0.43) | ALDH1A1CYP3A4TSHRKMT2A | |
| SCHEMBL1794794 | 0.76 | LMNA (0.55) | LMNAALDH1A1CYP3A4TSHRRECQL | |
| SCHEMBL9910290 | 0.72 | CDK1 (0.39) | LMNAALDH1A1CYP3A4TSHRKMT2A | |
| SCHEMBL12528205 | 0.71 | NOS2 (0.54) | NOS3NOS2ALDH1A1NOS1KMT2A | |
| SCHEMBL2603884 | 0.71 | MAPT (0.35) | CYP3A4KMT2A | |
| SCHEMBL1793425 | 0.69 | BRAF (0.46) | — | |
| SCHEMBL25277328 | 0.69 | KMT2A (0.52) | LMNANOS3NOS2ALDH1A1CASP1 | |
| SCHEMBL31290944 | 0.69 | ROCK2 (0.49) | CYP3A4ABL1 | |
| SCHEMBL24885851 | 0.69 | ROCK2 (0.49) | CYP3A4ABL1 | |
| SCHEMBL18688398 | 0.69 | SRC (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013207-B1 | IMIDAZO[4,5-B]PYRIDIN-2-ONE COMPOUNDS AND ANALOGS THEREOF AS CANCER THERAPEUTIC COMPOUNDS | CANCER REC TECH LTD (GB) | 2012-04-25 | — | — | EP | disclosed |