Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25358517 | 1.00 | DRD2 (0.33) | DRD2DRD3KMT2AL3MBTL1KDM1A | |
| SCHEMBL26040800 | 1.00 | DRD2 (0.33) | DRD2DRD3KMT2AL3MBTL1KDM1A | |
| SCHEMBL26039798 | 0.92 | F2R (0.31) | — | |
| SCHEMBL25360960 | 0.92 | F2R (0.31) | — | |
| SCHEMBL26040526 | 0.91 | — | — | |
| SCHEMBL26040591 | 0.89 | OPRK1 (0.31) | — | |
| SCHEMBL26040478 | 0.89 | — | — | |
| SCHEMBL26040527 | 0.89 | DRD2 (0.30) | DRD2 | |
| SCHEMBL26040397 | 0.89 | — | — | |
| SCHEMBL26040530 | 0.88 | OPRD1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154344-A1 | 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |