Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 5/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | JUN | P05412 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | GUSB | P08236 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26046303 | 0.85 | NFKB1 (0.62) | IAPPMAPTLMNAKDM4ENFKB1 | |
| SCHEMBL18503016 | 0.80 | IAPP (0.56) | IAPPMAPTLMNAKDM4ETDP1 | |
| SCHEMBL26046384 | 0.80 | IAPP (0.56) | IAPPMAPTLMNAKDM4ETDP1 | |
| SCHEMBL26046367 | 0.80 | KDM4E (0.67) | IAPPMAPTLMNAKDM4ENFE2L2 | |
| SCHEMBL8848033 | 0.79 | IAPP (0.66) | IAPPMAPTLMNANFKB1JUN | |
| SCHEMBL8848036 | 0.79 | IAPP (0.66) | IAPPMAPTLMNANFKB1JUN | |
| SCHEMBL13845332 | 0.79 | IAPP (0.38) | IAPPMAPTLMNAKDM4ENFKB1 | |
| SCHEMBL7177478 | 0.79 | IAPP (1.00) | IAPPMAPTLMNAKDM4ENFKB1 | |
| SCHEMBL26046362 | 0.79 | IAPP (1.00) | IAPPMAPTLMNAKDM4ENFKB1 | |
| SCHEMBL1404928 | 0.78 | MAPT (1.00) | IAPPMAPTLMNAKDM4ENFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11746364-B2 | Enzymatic synthesis of kavalactones and flavokavains | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-09-05 | — | — | US | disclosed |
| US-11739354-B2 | Enzymatic synthesis of kavalactones and flavokavains | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-08-29 | — | — | US | disclosed |