Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 5/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26046362 | 0.82 | IAPP (1.00) | IAPPLMNAMAPTPTGS1KDM4E | |
| SCHEMBL7177478 | 0.82 | IAPP (1.00) | IAPPLMNAMAPTPTGS1KDM4E | |
| SCHEMBL89143 | 0.82 | CA1 (0.57) | IAPPLMNAMAPTMAOBAPP | |
| SCHEMBL89145 | 0.82 | CA1 (0.57) | IAPPLMNAMAPTMAOBAPP | |
| SCHEMBL26046384 | 0.80 | IAPP (0.56) | IAPPLMNAMAPTMAOBPTGS1 | |
| SCHEMBL18503016 | 0.80 | IAPP (0.56) | IAPPLMNAMAPTMAOBPTGS1 | |
| SCHEMBL18509177 | 0.80 | IAPP (0.56) | IAPPLMNAMAPTPTGS1APP | |
| SCHEMBL8965182 | 0.80 | IAPP (0.54) | IAPPMAPTMAOBAPP | |
| SCHEMBL8965190 | 0.80 | IAPP (0.54) | IAPPMAPTMAOBAPP | |
| SCHEMBL26046382 | 0.78 | KDM4E (0.60) | IAPPLMNAMAPTAPPKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11746364-B2 | Enzymatic synthesis of kavalactones and flavokavains | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-09-05 | — | — | US | disclosed |
| US-11739354-B2 | Enzymatic synthesis of kavalactones and flavokavains | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-08-29 | — | — | US | disclosed |