Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 1/20 | 0.72 |
| ▸ | ERN1 | O75460 | 1/20 | 0.59 |
| ▸ | BACE1 | P56817 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | JUN | P05412 | 1/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7177478 | 1.00 | IAPP (1.00) | IAPPLMNAMAPTERN1BACE1 | |
| SCHEMBL29428452 | 0.84 | MAPT (1.00) | IAPPLMNAMAPTKDM4ENFKB1 | |
| SCHEMBL1404929 | 0.84 | MAPT (1.00) | IAPPLMNAMAPTKDM4ENFKB1 | |
| SCHEMBL1404928 | 0.84 | MAPT (1.00) | IAPPLMNAMAPTKDM4ENFKB1 | |
| SCHEMBL29377511 | 0.84 | MAPT (1.00) | IAPPLMNAMAPTKDM4ENFKB1 | |
| SCHEMBL1404990 | 0.83 | IAPP (0.71) | IAPPLMNAMAPTBACE1KDM4E | |
| SCHEMBL1404989 | 0.83 | IAPP (0.71) | IAPPLMNAMAPTBACE1KDM4E | |
| SCHEMBL307296 | 0.82 | NFKB1 (0.71) | IAPPLMNAMAPTERN1BACE1 | |
| SCHEMBL31083592 | 0.82 | NFKB1 (0.71) | IAPPLMNAMAPTERN1BACE1 | |
| SCHEMBL31256670 | 0.82 | NFKB1 (0.71) | IAPPLMNAMAPTERN1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11746364-B2 | Enzymatic synthesis of kavalactones and flavokavains | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-09-05 | — | — | US | disclosed |
| US-11739354-B2 | Enzymatic synthesis of kavalactones and flavokavains | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-08-29 | — | — | US | disclosed |