Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 4/20 | 0.57 |
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26046352 | 0.84 | POLB (0.45) | IAPPCTSKALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL26046416 | 0.82 | IAPP (0.45) | IAPPPRKCIALDH1A1PKMLMNA | |
| SCHEMBL26046412 | 0.82 | IAPP (0.70) | IAPPPRKCIALDH1A1LMNA | |
| SCHEMBL26046414 | 0.81 | IAPP (0.44) | IAPPALDH1A1LMNAPOLBSMN1; SMN2 | |
| SCHEMBL26046400 | 0.79 | IAPP (0.67) | IAPPALDH1A1PKMLMNAPOLB | |
| SCHEMBL26046465 | 0.78 | PRKCI (0.49) | IAPPPRKCIALDH1A1HTT | |
| SCHEMBL28606012 | 0.75 | IAPP (0.61) | IAPPPRKCIALDH1A1LMNAPOLB | |
| SCHEMBL25307580 | 0.73 | IAPP (0.53) | IAPPPRKCIALDH1A1LMNAPOLB | |
| SCHEMBL29131809 | 0.73 | IAPP (0.58) | IAPPPRKCI | |
| SCHEMBL26046392 | 0.73 | IAPP (1.00) | IAPPALDH1A1LMNAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11746364-B2 | Enzymatic synthesis of kavalactones and flavokavains | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-09-05 | — | — | US | disclosed |
| US-11739354-B2 | Enzymatic synthesis of kavalactones and flavokavains | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-08-29 | — | — | US | disclosed |