Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.40 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CDC25A | P30304 | 1/20 | 0.40 |
| ▸ | CDC25B | P30305 | 1/20 | 0.40 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.40 |
| ▸ | STAT6 | P42226 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | IAPP | P10997 | 3/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26046422 | 0.84 | IAPP (0.57) | POLBALDH1A1IAPPSMN1; SMN2CTSK | |
| SCHEMBL490950 | 0.81 | POLB (0.50) | POLBNPSR1IAPP | |
| SCHEMBL26046355 | 0.80 | POLB (0.55) | POLBNPSR1ALDH1A1FFAR1FFAR4 | |
| SCHEMBL1077642 | 0.80 | POLB (0.41) | POLBNPSR1ALDH1A1HSPA1AHSPA8 | |
| SCHEMBL26046358 | 0.79 | POLB (0.50) | POLBNPSR1HPGDALOX15HSD17B10 | |
| SCHEMBL26046345 | 0.79 | IAPP (0.46) | POLBNPSR1IAPPKEAP1FFAR1 | |
| SCHEMBL26046465 | 0.76 | PRKCI (0.49) | ALDH1A1HPGDALOX15HSD17B10IAPP | |
| SCHEMBL3735869 | 0.74 | POLB (0.58) | POLBALDH1A1KEAP1FFAR1FFAR4 | |
| SCHEMBL21317651 | 0.72 | POLB (0.58) | POLBNPSR1ALDH1A1IAPPFFAR1 | |
| SCHEMBL244943 | 0.72 | IAPP (0.70) | POLBNPSR1IAPPKEAP1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11746364-B2 | Enzymatic synthesis of kavalactones and flavokavains | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-09-05 | — | — | US | disclosed |
| US-11739354-B2 | Enzymatic synthesis of kavalactones and flavokavains | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2023-08-29 | — | — | US | disclosed |