Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR4 | P31391 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2609961 | 0.82 | SSTR4 (0.32) | SSTR4PDE3BPDE3A | |
| SCHEMBL21969672 | 0.77 | — | — | |
| SCHEMBL13439265 | 0.76 | — | — | |
| SCHEMBL24126814 | 0.76 | LMNA (0.33) | PDE3BPDE3A | |
| SCHEMBL22858641 | 0.74 | NOS2 (0.35) | — | |
| SCHEMBL34472956 | 0.72 | PDE3B (0.39) | PDE3BPDE3A | |
| SCHEMBL1131513 | 0.72 | PDE3B (0.39) | PDE3BPDE3A | |
| Ammonia Solution, Strong SCHEMBL28980458 | 0.70 | PDE3B (0.38) | PDE3BPDE3A | |
| SCHEMBL1132774 | 0.69 | TDP1 (0.35) | SSTR4PDE3BPDE3A | |
| SCHEMBL24135655 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8362019-B2 | Synthesis and anti-proliferative effect of substituted imidazo[4,5-b]pyrazine compounds | SPELMAN COLLEGE (US) | 2013-01-29 | — | — | US | disclosed |
| US-20120095009-A1 | SYNTHESIS AND ANTI-PROLIFERATIVE EFFECT OF BENZIMIDAZOLE DERIVATIVES | SPELMAN COLLEGE (US) | 2012-04-19 | — | — | US | disclosed |
| US-7947723-B2 | Synthesis and anti-proliferative effect of benzimidazole derivatives | SPELMAN COLLEGE (US) | 2011-05-24 | — | — | US | disclosed |
| US-20090197889-A1 | SYNTHESIS AND ANTI-PROLIFERATIVE EFFECT OF BENZIMIDAZOLE DERIVATIVES | SPELMAN COLLEGE (US) | 2009-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090197889-A1 | SYNTHESIS AND ANTI-PROLIFERATIVE EFFECT OF BENZIMIDAZOLE DERIVATIVES | MKI67, PCNA, CCNI | SSTR4 3138/4885PDE3B 1686/4885PDE3A 2090/4885 |
| US-20120095009-A1 | SYNTHESIS AND ANTI-PROLIFERATIVE EFFECT OF BENZIMIDAZOLE DERIVATIVES | MKI67, CCNI, TYMP | SSTR4 2009/4885PDE3B 576/4885PDE3A 951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.