Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.47 |
| ▸ | MEN1 | O00255 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL455957 | 0.76 | ALDH1A1 (0.58) | KMT2AMEN1ALDH1A1TSHRLMNA | |
| SCHEMBL3219108 | 0.74 | MAPK1 (0.49) | KMT2AMEN1ALDH1A1TSHRLMNA | |
| SCHEMBL9911538 | 0.74 | TSHR (0.56) | ALDH1A1TSHRLMNAL3MBTL1KDM4E | |
| SCHEMBL1645036 | 0.73 | SIGMAR1 (0.56) | ALDH1A1TSHRLMNAL3MBTL1KDM4E | |
| SCHEMBL14397069 | 0.73 | TSHR (0.57) | KMT2AMEN1ALDH1A1TSHRLMNA | |
| SCHEMBL7872338 | 0.73 | TSHR (0.53) | KMT2AMEN1ALDH1A1TSHRLMNA | |
| SCHEMBL15678236 | 0.72 | ALDH1A1 (0.49) | KMT2AMEN1ALDH1A1TSHRLMNA | |
| SCHEMBL8665636 | 0.72 | TSHR (0.56) | KMT2AMEN1ALDH1A1TSHRLMNA | |
| SCHEMBL3412211 | 0.72 | ALDH1A1 (0.52) | KMT2AMEN1ALDH1A1TSHRLMNA | |
| SCHEMBL25695968 | 0.71 | HTR7 (0.50) | KMT2AMEN1ALDH1A1TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163752-B2 | Tricyclic anilide heterocyclic CGRP receptor antagonists | Merck, Sharp & Dohme Corp. (US) | 2012-04-24 | — | — | US | disclosed |
| US-8133891-B2 | Tricyclic anilide spirolactam CGRP receptor antagonists | Merck, Sharp & Dohme Corp. (US) | 2012-03-13 | — | — | US | disclosed |