Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 2/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | ACACA | Q13085 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.32 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.32 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13649845 | 0.88 | PDK2 (0.40) | PDK2MAPK1POLBMAPTSMN1; SMN2 | |
| SCHEMBL10053610 | 0.88 | PDK2 (0.40) | PDK2MAPK1POLBMAPTSMN1; SMN2 | |
| SCHEMBL12864302 | 0.81 | PDK2 (0.46) | PDK2MAPK1POLBMAPTSMN1; SMN2 | |
| SCHEMBL2606066 | 0.77 | PDK2 (0.41) | PDK2 | |
| SCHEMBL2606070 | 0.76 | SRD5A2 (0.41) | PDK2POLBPTGS2PTGS1SMN1; SMN2 | |
| SCHEMBL2606064 | 0.74 | PDK2 (0.44) | PDK2POLBMAPTSMN1; SMN2LMNA | |
| SCHEMBL1167840 | 0.73 | TDP1 (0.52) | PDK2POLBMAPTSMN1; SMN2LMNA | |
| SCHEMBL13351678 | 0.73 | RAB9A (0.53) | MAPK1POLBMAPTSMN1; SMN2LMNA | |
| SCHEMBL2606061 | 0.73 | PDK2 (0.45) | PDK2POLBMAPTSMN1; SMN2LMNA | |
| SCHEMBL2605937 | 0.72 | CHRM5 (0.37) | PDK2POLBMAPTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2260023-B1 | FLUORENE DERIVATIVES FOR ORGANIC ELECTROLUMINESCENCE DEVICES | MERCK PATENT GMBH (DE) | 2012-04-25 | — | — | EP | disclosed |