Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | L3MBTL3 | Q96JM7 | 8/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MBTD1 | Q05BQ5 | 5/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2606456 | 0.85 | KDM4E (0.58) | KDM4EPOLBALDH1A1L3MBTL3GAA | |
| SCHEMBL2606351 | 0.82 | HPGD (0.58) | POLBALDH1A1L3MBTL3GAALMNA | |
| SCHEMBL4196427 | 0.81 | ACHE (0.59) | KDM4EL3MBTL3L3MBTL1MEN1KMT2A | |
| SCHEMBL13716161 | 0.77 | L3MBTL3 (0.62) | KDM4EPOLBTSHRALDH1A1L3MBTL3 | |
| SCHEMBL4703216 | 0.75 | GAA (0.68) | KDM4EPOLBALDH1A1GAARECQL | |
| SCHEMBL4703332 | 0.75 | KDM4E (0.57) | KDM4EPOLBTSHRL3MBTL3GAA | |
| SCHEMBL6045903 | 0.74 | HPGD (0.76) | KDM4ETSHRMAPK1ALDH1A1RECQL | |
| SCHEMBL999166 | 0.74 | KDM4E (0.41) | KDM4EMAPK1 | |
| SCHEMBL2606376 | 0.73 | C3AR1 (0.49) | KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL2606343 | 0.73 | HTT (0.48) | MAPK1ALDH1A1TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2444397-A1 | Heteroaryl-ureas and their use as glucokinase activators | Novo Nordisk A/S (DK) | 2012-04-25 | — | — | EP | disclosed |