Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.76 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | NAMPT | P43490 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 2/20 | 0.56 |
| ▸ | CA2 | P00918 | 2/20 | 0.56 |
| ▸ | CA7 | P43166 | 2/20 | 0.56 |
| ▸ | CA9 | Q16790 | 2/20 | 0.56 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12490113 | 0.98 | HPGD (0.72) | HPGDALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL21987038 | 0.93 | HPGD (0.71) | HPGDALDH1A1TSHRMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL1597604 | 0.87 | TSHR (0.64) | HPGDALDH1A1TSHRKDM4ETP53 | |
| SCHEMBL27479149 | 0.87 | HPGD (1.00) | HPGDALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL7132525 | 0.87 | HPGD (1.00) | HPGDALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL10838586 | 0.87 | HPGD (0.62) | HPGDALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL2677744 | 0.85 | KDM4E (0.57) | HPGDALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL24092731 | 0.84 | HPGD (0.59) | HPGDALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL10721733 | 0.84 | HPGD (0.95) | HPGDALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL27947458 | 0.83 | HPGD (0.53) | HPGDALDH1A1TSHRRECQLKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235091-A1 | NOVEL HETEROCYCLIC COMPOUND AND USE THEREOF | 엠비디 주식회사 | 2022-11-10 | — | — | WO | claimed |
| US-20230183222-A1 | 8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | GRUENENTHAL GMBH (DE) | 2023-06-15 | — | — | US | disclosed |
| WO-2022235091-A1 | NOVEL HETEROCYCLIC COMPOUND AND USE THEREOF | 엠비디 주식회사 | 2022-11-10 | — | — | WO | disclosed |
| US-10793556-B2 | 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives | GRUENENTHAL GMBH (DE) | 2020-10-06 | — | — | US | disclosed |
| CN-108997311-A | Bis- aryl methylene -4- the piperidones of 3,5- and preparation method thereof that asymmetric 4- pyridine replaces | 滨州医学院 | 2018-12-14 | — | — | CN | disclosed |
| US-20170209441-A1 | AMINOQUINOLINE DERIVATIVES AND USES THEREOF | UNIVERSITY OF DELHI (IN) | 2017-07-27 | — | — | US | disclosed |
| US-9567316-B2 | Aminoquinoline derivatives and uses thereof | THE MCLEAN HOSPITAL CORPORATION (US) | 2017-02-14 | — | — | US | disclosed |
| US-20150023930-A1 | AMINOQUINOLINE DERIVATIVES AND USES THEREOF | THE MCLEAN HOSPITAL CORPORATION (US) | 2015-01-22 | — | — | US | disclosed |
| EP-2343069-A1 | Heterocyclic aspartyl protease inhibitors | Schering Corporation (US) | 2011-07-13 | — | — | EP | disclosed |
| EP-2335701-A1 | Heterocyclic aspartyl protease inhibitors | Schering Corporation (US) | 2011-06-22 | — | — | EP | disclosed |
| US-20060281733-A1 | 4-Bromo-5-(2-chloro-benzoylamino)-1h-pyrazole-3-carvoxylic acid amide derivatives and related compounds as bradykinin b1 receptor antagonists for the treatment of inflammatory diseases | ELAN PHARMACEUTICALS, INC. | 2006-12-14 | — | — | US | disclosed |
| WO-2006123257-A2 | PHENYL-3-{(3-(1H-PYRROL-2-YL)-[1, 2 , 4]0XADIAZ0L-5-YL]PIPERIDIN-1-YL}-METHANONE DERIVATIVES AND RELATED COMPOUNDS AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA SA (CH) | 2006-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150023930-A1 | AMINOQUINOLINE DERIVATIVES AND USES THEREOF | LRRK2, NLN, AADAT | HPGD 879/4885ALDH1A1 2094/4885TSHR 3722/4885 |
| US-10793556-B2 | 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives | OPRK1, OPRD1, OPRL1 | HPGD 752/4885ALDH1A1 250/4885TSHR 2683/4885 |
| US-20230183222-A1 | 8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives | OPRK1, OPRD1, OPRL1 | HPGD 752/4885ALDH1A1 250/4885TSHR 2683/4885 |
| US-20060281733-A1 | 4-Bromo-5-(2-chloro-benzoylamino)-1h-pyrazole-3-carvoxylic acid amide derivatives and related compounds as bradykinin b1 receptor antagonists for the treatment of inflammatory diseases | BDKRB1, BDKRB2, CNR1 | HPGD 797/4885ALDH1A1 2017/4885TSHR 1309/4885 |
| US-20170209441-A1 | AMINOQUINOLINE DERIVATIVES AND USES THEREOF | LRRK2, NLRP3, AADAT | HPGD 1667/4885ALDH1A1 1990/4885TSHR 3618/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.