Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | LMNA | P02545 | 6/20 | 0.44 |
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24920554 | 0.82 | LMNA (0.50) | POLBSMN1; SMN2MAPTLMNATP53 | |
| SCHEMBL25677916 | 0.76 | HTR2C (0.56) | POLBSMN1; SMN2MAPTLMNAHSP90AB1 | |
| SCHEMBL8898686 | 0.76 | SMN1; SMN2 (0.54) | POLBSMN1; SMN2MAPTLMNATP53 | |
| SCHEMBL28516998 | 0.75 | MAPT (0.52) | POLBSMN1; SMN2MAPTLMNATP53 | |
| SCHEMBL30405241 | 0.75 | MAPT (0.52) | POLBSMN1; SMN2MAPTLMNATP53 | |
| SCHEMBL22720338 | 0.75 | SMN1; SMN2 (0.76) | POLBSMN1; SMN2MAPTLMNA | |
| Hydrochloric Acid SCHEMBL8898072 | 0.75 | SMN1; SMN2 (0.52) | POLBSMN1; SMN2MAPTLMNAHSP90AB1 | |
| SCHEMBL24920545 | 0.74 | POLB (0.46) | POLBSMN1; SMN2MAPTLMNATP53 | |
| SCHEMBL21528007 | 0.72 | MAPT (0.77) | MAPTHSP90AB1 | |
| SCHEMBL31046962 | 0.72 | MAPT (0.77) | MAPTHSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4234031-A2 | C40-, C28-, AND C-32-LINKED RAPAMYCIN ANALOGS AS MTOR INHIBITORS | Revolution Medicines, Inc. (US) | 2023-08-30 | — | — | EP | disclosed |