Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 4/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | ITGAV | P06756 | 5/20 | 0.38 |
| ▸ | ITGB5 | P18084 | 5/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26066699 | 0.86 | HDAC1 (0.43) | FOLH1LMNAMAOAMAOBFNTA | |
| SCHEMBL21232620 | 0.83 | FOLH1 (0.39) | FOLH1ITGAVITGB5MAOAMAOB | |
| SCHEMBL26066648 | 0.83 | FOLH1 (0.41) | FOLH1KMT2APOLBITGAVITGB5 | |
| SCHEMBL21232781 | 0.80 | ITGAV (0.40) | KMT2APOLBITGAVITGB5MAOA | |
| SCHEMBL21063617 | 0.76 | MAOA (0.47) | KMT2APOLBITGAVITGB5MAOA | |
| SCHEMBL18632997 | 0.76 | MAOA (0.44) | KMT2APOLBITGAVITGB5MAOA | |
| SCHEMBL15257805 | 0.74 | MAOA (0.43) | KMT2APOLBITGAVITGB5MAOA | |
| SCHEMBL12825187 | 0.72 | MAOA (0.42) | MAOAMAOB | |
| SCHEMBL25013920 | 0.72 | GBA1 (0.43) | MAOA | |
| SCHEMBL23876336 | 0.72 | MAOA (0.38) | FOLH1MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154344-A1 | 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |