Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 2/20 | 0.37 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.34 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15801448 | 1.00 | TERT (0.37) | TERTANPEPDNPEPPSEN1PSEN2 | |
| Hydrochloric Acid SCHEMBL15792148 | 0.98 | TERT (0.36) | TERTANPEPDNPEPPSEN1PSEN2 | |
| Hydrochloric Acid SCHEMBL15792150 | 0.98 | TERT (0.36) | TERTANPEPDNPEPPSEN1PSEN2 | |
| SCHEMBL9151 | 0.83 | KMT2A (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL17152599 | 0.82 | ANPEP (0.44) | ANPEPDNPEPDPP7S1PR2S1PR1 | |
| SCHEMBL12391779 | 0.82 | SIGMAR1 (0.39) | TERTANPEPDNPEPDPP4USP2 | |
| SCHEMBL4115911 | 0.81 | DPP4 (0.40) | ANPEPDNPEPPSEN1PSEN2APH1B | |
| SCHEMBL9140084 | 0.80 | USP2 (0.50) | TERTANPEPDNPEPDPP4USP2 | |
| SCHEMBL9140089 | 0.80 | USP2 (0.50) | TERTANPEPDNPEPDPP4USP2 | |
| SCHEMBL2580662 | 0.79 | CTSS (0.40) | TERTPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154344-A1 | 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |