Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 8/20 | 0.41 |
| ▸ | JAK2 | O60674 | 8/20 | 0.41 |
| ▸ | JAK3 | P52333 | 8/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29395849 | 1.00 | PTK2 (0.41) | PTK2JAK2JAK3NR1H2DRD2 | |
| SCHEMBL26072112 | 0.91 | MAP4K1 (0.38) | PTK2JAK2JAK3 | |
| SCHEMBL29393670 | 0.91 | MAP4K1 (0.38) | PTK2JAK2JAK3 | |
| SCHEMBL29396209 | 0.89 | JAK2 (0.42) | PTK2JAK2JAK3NR1H2DRD2 | |
| SCHEMBL26072319 | 0.89 | JAK2 (0.42) | PTK2JAK2JAK3NR1H2DRD2 | |
| SCHEMBL29393611 | 0.84 | NAMPT (0.35) | PTK2JAK2JAK3NOS3NOS1 | |
| SCHEMBL26072403 | 0.84 | NAMPT (0.35) | PTK2JAK2JAK3NOS3NOS1 | |
| SCHEMBL26381064 | 0.82 | VCP (0.40) | PTK2JAK2JAK3NR1H2DRD2 | |
| SCHEMBL26072181 | 0.81 | JAK2 (0.41) | PTK2JAK2JAK3NR1H2NOS3 | |
| SCHEMBL26072039 | 0.80 | GPR119 (0.34) | PTK2JAK2JAK3NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230312565-A1 | 1H-PYRROLO[3,2-C]PYRIDINE AND 1H-PYRROLO[2,3-C]PYRIDINE DERIVATIVES AS TLR9 INHIBITORS FOR THE TREATMENT OF FIBROSIS | BRISTOL MYERS SQUIBB CO (US) | 2023-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230312565-A1 | 1H-PYRROLO[3,2-C]PYRIDINE AND 1H-PYRROLO[2,3-C]PYRIDINE DERIVATIVES AS TLR9 INHIBITORS FOR THE TREATMENT OF FIBROSIS | TLR9, TLR1, TLR7 | PTK2 563/4885JAK2 137/4885JAK3 240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.