Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 7/20 | 0.36 |
| ▸ | AXL | P30530 | 5/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | HPD | P32754 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21785269 | 0.85 | MET (0.43) | GSK3AGSK3BALDH1A1L3MBTL1KDM4E | |
| SCHEMBL24878914 | 0.80 | GSK3A (0.44) | GSK3AGSK3BALDH1A1L3MBTL1KDM4E | |
| SCHEMBL24878915 | 0.80 | MAPT (0.42) | ALDH1A1L3MBTL1METAXLPOLB | |
| SCHEMBL14969174 | 0.77 | KDM4E (0.43) | GSK3AGSK3BL3MBTL1KDM4EMET | |
| SCHEMBL21785860 | 0.77 | AXL (0.36) | GSK3AGSK3BALDH1A1L3MBTL1KDM4E | |
| SCHEMBL23749310 | 0.76 | AXL (0.41) | GSK3AGSK3BL3MBTL1METAXL | |
| SCHEMBL29814160 | 0.76 | AXL (0.41) | GSK3AGSK3BMETAXLMERTK | |
| SCHEMBL21785268 | 0.76 | GSK3A (0.40) | GSK3AGSK3BALDH1A1L3MBTL1KDM4E | |
| SCHEMBL23071265 | 0.74 | LMNA (0.46) | ALDH1A1KDM4EMETAXLPOLB | |
| SCHEMBL23070989 | 0.73 | PLA2G4A (0.36) | GSK3AGSK3BALDH1A1L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11780835-B2 | Pyrazolo[3,4-b]pyridine compounds as inhibitors of TAM and MET kinases | ARRAY BIOPHARMA INC. (US) | 2023-10-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11780835-B2 | Pyrazolo[3,4-b]pyridine compounds as inhibitors of TAM and MET kinases | RET, MERTK, MET | GSK3A 506/4885GSK3B 409/4885ALDH1A1 2121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.