Sugi Predict

Sugi Predict / Compounds / SCHEMBL260853

SCHEMBL260853

SCHEMBL260853

COC(=O)c1ncc(Cl)nc1N

nearest known ligand 0.45

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ NPSR1 Q6W5P4 1/20 0.45
▸ KDM4E B2RXH2 6/20 0.42
▸ PKM P14618 3/20 0.42
▸ ALDH1A1 P00352 3/20 0.42
▸ SMN1; SMN2 Q16637 2/20 0.42
▸ L3MBTL1 Q9Y468 2/20 0.42
▸ GRM5 P41594 2/20 0.42
▸ MAPKAPK2 P49137 7/20 0.40
▸ PIK3CD O00329 1/20 0.40
▸ RCE1 Q9Y256 1/20 0.40
▸ HPGD P15428 1/20 0.38
▸ HSD17B10 Q99714 1/20 0.38
▸ TSHR P16473 1/20 0.38
▸ ABL1 P00519 1/20 0.37
▸ MAPK1 P28482 1/20 0.37
▸ GLA P06280 1/20 0.37
▸ GAA P10253 1/20 0.37
▸ PLAU P00749 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29410004 1.00 NPSR1 (0.45) NPSR1KDM4EPKMALDH1A1SMN1; SMN2
SCHEMBL29844710 0.88 GRM5 (0.52) NPSR1KDM4EPKMALDH1A1SMN1; SMN2
SCHEMBL261816 0.88 GRM5 (0.52) NPSR1KDM4EPKMALDH1A1SMN1; SMN2
SCHEMBL20046668 0.84 NPSR1 (0.56) NPSR1KDM4EPKMALDH1A1SMN1; SMN2
SCHEMBL1680511 0.82 PLAU (0.53) NPSR1KDM4EPKMALDH1A1SMN1; SMN2
SCHEMBL4014560 0.82 NPSR1 (0.48) NPSR1KDM4EPKMALDH1A1SMN1; SMN2
SCHEMBL29585697 0.82 NPSR1 (0.48) NPSR1KDM4EPKMALDH1A1SMN1; SMN2
SCHEMBL25399004 0.81 NPSR1 (0.47) NPSR1KDM4EPKMALDH1A1SMN1; SMN2
SCHEMBL361753 0.81 NPSR1 (0.47) NPSR1KDM4EPKMALDH1A1SMN1; SMN2
SCHEMBL12248189 0.81 NPSR1 (0.47) NPSR1KDM4EPKMALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 93 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115215923-B Macrocyclic broad-spectrum antibiotics 豪夫迈·罗氏有限公司 2026-05-19 — — CN disclosed
WO-2025106383-A1 PYRROLIDINYL DERIVATIVES USEFUL AS HCN1/HCN 2 MODULATORS MERCK SHARP & DOHME LLC (US) 2025-05-22 — — WO disclosed
US-20240270759-A1 Preparation of SHP2 phosphatase inhibitors and its applications YA THERAPEUTICS INC (CN) 2024-08-15 — — US disclosed
CN-115960109-B Preparation and application of condensed ring SHP2 phosphatase inhibitor 药雅科技(上海)有限公司 2024-06-25 — — CN disclosed
EP-4289480-A2 MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS F. Hoffmann-La Roche AG (CH) 2023-12-13 — — EP disclosed
EP-4289480-A2 MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS F. Hoffmann-La Roche AG (CH) 2023-12-13 — — EP disclosed
CN-115960109-A Preparation and application of fused-ring SHP2 phosphatase inhibitor 药雅科技(上海)有限公司 2023-04-14 — — CN disclosed
WO-2022237676-A1 PREPARATION AND APPLICATION OF SHP2 PHOSPHATASE INHIBITOR 药雅科技(上海)有限公司 2022-11-17 — — WO disclosed
CN-115215923-A Macrocyclic broad spectrum antibiotics 豪夫迈·罗氏有限公司 2022-10-21 — — CN disclosed
CN-114007605-B Macrocyclic broad spectrum antibiotics 豪夫迈·罗氏有限公司 2022-07-15 — — CN disclosed
US-20090305892-A1 PYRIDO[2,3-B]PYRAZINE DERIVATIVES USEFUL AS HERBICIDAL COMPOUNDS SYNGENTA LIMITED (GB) 2009-12-10 — — US disclosed
US-20090305892-A1 PYRIDO[2,3-B]PYRAZINE DERIVATIVES USEFUL AS HERBICIDAL COMPOUNDS SYNGENTA LIMITED (GB) 2009-12-10 — — US disclosed
CN-101490051-A Pyrido [2, 3-b] pyrazine derivatives useful as herbicidal compounds SYNGENTA LTD (GB) 2009-07-22 — — CN disclosed
EP-2057154-A1 PYRIDO [2, 3-B]PYRAZINE DERIVATIVES USEFUL AS HERBICIDAL COMPOUNDS Syngenta Limited (GB) 2009-05-13 — — EP disclosed
US-20090099171-A1 Diazaquinolones that inhibit prolyl hydroxylase activity AMGEN INC. (US) 2009-04-16 — — US disclosed
WO-2008137084-A2 DIAZAQUINOLONES THAT INHIBIT PROLYL HYDROXYLASE ACTIVITY AMGEN INC. (US) 2008-11-13 — — WO disclosed
WO-2008009908-A1 PYRIDO [2, 3-B] PYRAZINE DERIVATIVES USEFUL AS HERBICIDAL COMPOUNDS SYNGENTA LIMITED (GB) 2008-01-24 — — WO disclosed
WO-2008009908-A1 PYRIDO [2, 3-B] PYRAZINE DERIVATIVES USEFUL AS HERBICIDAL COMPOUNDS SYNGENTA LIMITED (GB) 2008-01-24 — — WO disclosed
US-20070191374-A1 Substituted cinnolin-4-ylamines NEUROGEN COROPERATION (US) 2007-08-16 — — US disclosed
US-20070191374-A1 Substituted cinnolin-4-ylamines NEUROGEN COROPERATION (US) 2007-08-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070191374-A1 Substituted cinnolin-4-ylamines CNR1, GPR174, CNR2 NPSR1 70/4885KDM4E 3499/4885PKM 2774/4885
US-20090099171-A1 Diazaquinolones that inhibit prolyl hydroxylase activity EGLN3, EGLN2, HIF1AN NPSR1 2774/4885KDM4E 248/4885PKM 1104/4885
US-20240270759-A1 Preparation of SHP2 phosphatase inhibitors and its applications PTPN2, PTPN22, PTPN5 NPSR1 3170/4885KDM4E 861/4885PKM 2893/4885
US-20090305892-A1 PYRIDO[2,3-B]PYRAZINE DERIVATIVES USEFUL AS HERBICIDAL COMPOUNDS PNPO, CBR3, CBR1 NPSR1 1170/4885KDM4E 2152/4885PKM 724/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.