Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 5/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.33 |
| ▸ | PSMB2 | P49721 | 3/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LONP1 | P36776 | 3/20 | 0.33 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.33 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.33 |
| ▸ | PSMA1 | P25786 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9474835 | 0.84 | KDM4E (0.50) | KDM4EALDH1A1SMN1; SMN2PSMB5NLRP3 | |
| SCHEMBL30638522 | 0.84 | KDM4E (0.50) | KDM4EALDH1A1SMN1; SMN2PSMB5NLRP3 | |
| SCHEMBL6966444 | 0.81 | POLB (0.37) | KDM4EALDH1A1SMN1; SMN2PSMB5NLRP3 | |
| SCHEMBL5706459 | 0.81 | KDM4E (0.36) | KDM4EALDH1A1SMN1; SMN2PSMB5NLRP3 | |
| SCHEMBL6965886 | 0.81 | POLB (0.37) | KDM4EALDH1A1SMN1; SMN2PSMB5NLRP3 | |
| SCHEMBL8105929 | 0.81 | POLB (0.37) | KDM4EALDH1A1SMN1; SMN2PSMB5NLRP3 | |
| SCHEMBL18462726 | 0.80 | KDM4E (0.38) | KDM4EALDH1A1SMN1; SMN2PSMB5NLRP3 | |
| SCHEMBL20061662 | 0.80 | ALDH1A1 (0.38) | KDM4EALDH1A1SMN1; SMN2PSMB5NLRP3 | |
| SCHEMBL29364563 | 0.79 | KDM4E (0.40) | KDM4EALDH1A1SMN1; SMN2PSMB5NLRP3 | |
| SCHEMBL510583 | 0.79 | KDM4E (0.40) | KDM4EALDH1A1SMN1; SMN2PSMB5NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230312490-A1 | MCL-1 INHIBITORS | GILEAD SCIENCES, INC. | 2023-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230312490-A1 | MCL-1 INHIBITORS | MCL1, BCL2L1, BCL2 | KDM4E 2079/4885ALDH1A1 1991/4885SMN1; SMN2 1771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.