Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | VNN1 | O95497 | 1/20 | 0.32 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6965886 | 1.00 | POLB (0.37) | POLBKDM4EALDH1A1SMN1; SMN2HDAC3 | |
| SCHEMBL6966444 | 1.00 | POLB (0.37) | POLBKDM4EALDH1A1SMN1; SMN2HDAC3 | |
| SCHEMBL28322787 | 0.82 | DAO (0.38) | POLBKDM4EALDH1A1SMN1; SMN2HDAC3 | |
| SCHEMBL26085643 | 0.81 | KDM4E (0.43) | POLBKDM4EALDH1A1SMN1; SMN2HDAC3 | |
| SCHEMBL5706459 | 0.81 | KDM4E (0.36) | POLBKDM4EALDH1A1SMN1; SMN2HDAC3 | |
| SCHEMBL7109077 | 0.78 | LMNA (0.31) | — | |
| SCHEMBL7109071 | 0.78 | LMNA (0.31) | — | |
| SCHEMBL7107159 | 0.78 | LMNA (0.31) | — | |
| SCHEMBL6094582 | 0.77 | HSP90AA1 (0.35) | POLBKDM4EALDH1A1SMN1; SMN2HDAC3 | |
| SCHEMBL20278973 | 0.77 | HSP90AA1 (0.35) | POLBKDM4EALDH1A1SMN1; SMN2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1264368-A | Polyhydroxybutylpyrazines, process for their preparation and medicaments containing them | RHONE POULENC RORER SA (FR) | 2000-08-23 | — | — | CN | disclosed |
| EP-1001943-A1 | POLYHYDROXYALKYLPYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | Aventis Pharma S.A. (FR) | 2000-05-24 | — | — | EP | disclosed |
| US-5972342-A | ANTIDIABETIC AGENTS | RHONE-POULENC RORER S.A. (FR) | 1999-10-26 | — | — | US | disclosed |
| WO-1999003843-A1 | POLYHYDROXYALKYLPYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | RHONE-POULENC RORER S.A. (FR) | 1999-01-28 | — | — | WO | disclosed |