Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17666921 | 0.76 | CTSK (0.46) | KDM4EALDH1A1GAANPSR1ALOX12 | |
| SCHEMBL26088656 | 0.72 | ALDH1A1 (0.46) | KDM4EALDH1A1GAANPSR1POLB | |
| SCHEMBL26091858 | 0.72 | ALDH1A1 (0.46) | KDM4EALDH1A1GAANPSR1POLB | |
| SCHEMBL26091033 | 0.69 | KDM4E (0.33) | KDM4EALDH1A1GAANPSR1ALOX12 | |
| SCHEMBL26091036 | 0.69 | KDM4E (0.33) | KDM4EALDH1A1GAANPSR1ALOX12 | |
| SCHEMBL1642699 | 0.65 | KDM4E (0.52) | KDM4EGAANPSR1HTTPOLB | |
| SCHEMBL20821435 | 0.63 | — | — | |
| SCHEMBL29930300 | 0.63 | — | — | |
| SCHEMBL14058781 | 0.62 | KDM4E (0.33) | KDM4EALDH1A1GAANPSR1ALOX12 | |
| SCHEMBL14058780 | 0.62 | KDM4E (0.33) | KDM4EALDH1A1GAANPSR1ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023067515-A1 | THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2023-04-27 | — | — | WO | disclosed |
| WO-2023067515-A1 | THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2023-04-27 | — | — | WO | disclosed |