Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.42 |
| ▸ | HBB | P68871 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.36 |
| ▸ | FEN1 | P39748 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5171558 | 0.82 | KMT2A (0.63) | KEAP1KDM4EMEN1KMT2APOLB | |
| SCHEMBL12593846 | 0.78 | KEAP1 (0.62) | KEAP1KDM4EMEN1KMT2APOLB | |
| SCHEMBL4064464 | 0.78 | KEAP1 (0.77) | KEAP1KDM4EMEN1KMT2APOLB | |
| SCHEMBL4712158 | 0.76 | HSPB1 (0.51) | KDM4EMEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL4065605 | 0.75 | KEAP1 (0.59) | KEAP1KDM4EMEN1KMT2APOLB | |
| SCHEMBL4717640 | 0.74 | KDM4E (0.64) | KEAP1KDM4EMEN1KMT2APOLB | |
| SCHEMBL4070182 | 0.73 | KEAP1 (0.60) | KEAP1KDM4EMEN1KMT2APOLB | |
| SCHEMBL4061973 | 0.73 | KDM4E (0.60) | KEAP1KDM4EMEN1KMT2APOLB | |
| SCHEMBL12594180 | 0.72 | KEAP1 (0.52) | KEAP1KDM4EMEN1KMT2APOLB | |
| SCHEMBL1014038 | 0.72 | KEAP1 (1.00) | KEAP1KDM4EMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230139808-A1 | 4-(METHYLAMINOPHENOXY)PYRDIN-3-YL-BENZAMIDE DERIVATIVES FOR TREATING CANCER | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2023-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230139808-A1 | 4-(METHYLAMINOPHENOXY)PYRDIN-3-YL-BENZAMIDE DERIVATIVES FOR TREATING CANCER | HCCS, IDH2, MDH2 | KEAP1 442/4885KDM4E 446/4885MEN1 639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.