Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | SHMT2 | P34897 | 2/20 | 0.41 |
| ▸ | DAO | P14920 | 4/20 | 0.40 |
| ▸ | GSK3A | P49840 | 5/20 | 0.38 |
| ▸ | GSK3B | P49841 | 5/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.38 |
| ▸ | CDK1 | P06493 | 4/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.36 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2294638 | 0.72 | ALDH1A1 (0.53) | KDM5ADAOKDM4EALDH1A1AURKA | |
| SCHEMBL4754656 | 0.72 | KDM4E (0.53) | KDM5ADAOKDM4EALDH1A1MAPT | |
| SCHEMBL30575356 | 0.72 | ALDH1A1 (0.53) | KDM5ADAOKDM4EALDH1A1AURKA | |
| SCHEMBL12590225 | 0.67 | MAPK1 (0.44) | GSK3AGSK3BCDK5CCNB2CDK1 | |
| SCHEMBL17819122 | 0.65 | DAO (0.39) | KDM5ASHMT2DAOKDM4EALDH1A1 | |
| SCHEMBL8692333 | 0.64 | GRIN2D (0.50) | KDM5ADAOKDM4EALDH1A1MEN1 | |
| SCHEMBL16767848 | 0.64 | DAO (0.56) | DAOGSK3AGSK3BCDK5CCNB2 | |
| SCHEMBL932546 | 0.64 | KDM4E (0.46) | GSK3AGSK3BCDK5KDM4EALDH1A1 | |
| SCHEMBL29545868 | 0.64 | KDM4E (0.46) | GSK3AGSK3BCDK5KDM4EALDH1A1 | |
| SCHEMBL13348756 | 0.63 | KDM4E (0.43) | KDM5ASHMT2DAOKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057154-B1 | PYRIDO [2, 3-B]PYRAZINE DERIVATIVES USEFUL AS HERBICIDAL COMPOUNDS | SYNGENTA LTD (GB) | 2012-11-14 | — | — | EP | disclosed |
| EP-2057154-B1 | PYRIDO [2, 3-B]PYRAZINE DERIVATIVES USEFUL AS HERBICIDAL COMPOUNDS | SYNGENTA LTD (GB) | 2012-11-14 | — | — | EP | disclosed |
| US-8133847-B2 | Pyrido[2,3-B]pyrazine derivatives useful as herbicidal compounds | SYNGENTA LIMITED (GB) | 2012-03-13 | — | — | US | disclosed |
| US-8133847-B2 | Pyrido[2,3-B]pyrazine derivatives useful as herbicidal compounds | SYNGENTA LIMITED (GB) | 2012-03-13 | — | — | US | disclosed |
| US-8133847-B2 | Pyrido[2,3-B]pyrazine derivatives useful as herbicidal compounds | SYNGENTA LIMITED (GB) | 2012-03-13 | — | — | US | disclosed |
| US-20090305892-A1 | PYRIDO[2,3-B]PYRAZINE DERIVATIVES USEFUL AS HERBICIDAL COMPOUNDS | SYNGENTA LIMITED (GB) | 2009-12-10 | — | — | US | disclosed |
| US-20090305892-A1 | PYRIDO[2,3-B]PYRAZINE DERIVATIVES USEFUL AS HERBICIDAL COMPOUNDS | SYNGENTA LIMITED (GB) | 2009-12-10 | — | — | US | disclosed |
| US-20090305892-A1 | PYRIDO[2,3-B]PYRAZINE DERIVATIVES USEFUL AS HERBICIDAL COMPOUNDS | SYNGENTA LIMITED (GB) | 2009-12-10 | — | — | US | disclosed |
| EP-2057154-A1 | PYRIDO [2, 3-B]PYRAZINE DERIVATIVES USEFUL AS HERBICIDAL COMPOUNDS | Syngenta Limited (GB) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008009908-A1 | PYRIDO [2, 3-B] PYRAZINE DERIVATIVES USEFUL AS HERBICIDAL COMPOUNDS | SYNGENTA LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |
| WO-2008009908-A1 | PYRIDO [2, 3-B] PYRAZINE DERIVATIVES USEFUL AS HERBICIDAL COMPOUNDS | SYNGENTA LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |
| EP-0267740-A1 | Naphthyridine and pyridopyrazine compounds and pharmaceutical usage thereof | SCHERING CORPORATION (US) | 1988-05-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090305892-A1 | PYRIDO[2,3-B]PYRAZINE DERIVATIVES USEFUL AS HERBICIDAL COMPOUNDS | PNPO, CBR3, CBR1 | KDM5A 391/4885SHMT2 844/4885DAO 138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.