Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | KCNJ1 | P48048 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26548211 | 0.92 | GBA1 (0.53) | GBA1ALDH1A1KDM4EKCNJ1LMNA | |
| SCHEMBL378000 | 0.74 | GBA1 (0.54) | GBA1ALDH1A1KDM4EKCNJ1LMNA | |
| SCHEMBL3401703 | 0.74 | GBA1 (0.54) | GBA1ALDH1A1KDM4EKCNJ1LMNA | |
| SCHEMBL26097936 | 0.73 | JAK1 (0.53) | GBA1ALDH1A1LMNAJAK1JAK3 | |
| SCHEMBL3156675 | 0.73 | HRH3 (0.63) | GBA1ALDH1A1KDM4EKCNJ1LMNA | |
| SCHEMBL30361409 | 0.72 | GBA1 (0.58) | GBA1ALDH1A1KDM4EKCNJ1LMNA | |
| SCHEMBL14564424 | 0.70 | ALDH1A1 (0.70) | ALDH1A1KDM4EKCNJ1LMNASMN1; SMN2 | |
| SCHEMBL626660 | 0.69 | KCNJ1 (0.72) | ALDH1A1KDM4EKCNJ1LMNASMN1; SMN2 | |
| SCHEMBL10759713 | 0.69 | TRPV6 (0.47) | GBA1ALDH1A1KDM4EKCNJ1LMNA | |
| SCHEMBL13527054 | 0.69 | ALDH1A1 (0.58) | ALDH1A1KDM4EKCNJ1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230133132-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. | 2023-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230133132-A1 | NAMPT MODULATORS | NAMPT, MC4R, SIRT1 | GBA1 2683/4885ALDH1A1 2019/4885KDM4E 2721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.