Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 2/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 9/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 8/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HTR1F | P30939 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2610205 | 0.91 | CHRM1 (0.49) | CTSSCHRM1CHRM2CHRM4CYP2D6 | |
| SCHEMBL2114521 | 0.88 | CTSS (0.44) | CTSSCHRM1CHRM2CHRM4NPC1 | |
| SCHEMBL2610208 | 0.86 | CTSS (0.57) | CTSSCHRM1CHRM2CHRM4CYP2D6 | |
| SCHEMBL2114772 | 0.85 | CTSS (0.44) | CTSSCHRM1CHRM2CHRM4 | |
| SCHEMBL2710775 | 0.79 | CHRM1 (0.47) | CTSSCHRM1CHRM2CHRM4LMNA | |
| SCHEMBL2113188 | 0.79 | CHRM1 (0.46) | CTSSCHRM1CHRM2CHRM4LMNA | |
| SCHEMBL2610209 | 0.78 | CTSS (0.52) | CTSSCHRM1CHRM2CHRM4HDAC3 | |
| SCHEMBL2113907 | 0.78 | CHRM1 (0.54) | CTSSCHRM1CHRM2CHRM4NPC1 | |
| Hydrochloric Acid SCHEMBL2115298 | 0.77 | CTSS (0.51) | CTSSCHRM1CHRM2CHRM4HDAC3 | |
| SCHEMBL2113359 | 0.77 | CTSS (0.53) | CTSSCHRM1CHRM2CHRM4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8227468-B2 | Cathepsin S inhibitor compounds | ELI LILLY AND COMPANY (US) | 2012-07-24 | — | — | US | disclosed |
| US-20120095020-A1 | Cathepsin S Inhibitor Compounds | ELI LILLY AND COMPANY (US) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095020-A1 | Cathepsin S Inhibitor Compounds | CTSS, CTSZ, CTSV | CTSS 1/4885CHRM1 4241/4885CHRM2 4275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.