Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.40 |
| ▸ | ADK | P55263 | 6/20 | 0.39 |
| ▸ | USP1 | O94782 | 1/20 | 0.38 |
| ▸ | USP19 | O94966 | 1/20 | 0.38 |
| ▸ | UCHL3 | P15374 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.34 |
| ▸ | GCGR | P47871 | 2/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26104108 | 0.77 | EGFR (0.49) | EGFRCYP1A2CYP2C9HPGDCYP2C19 | |
| SCHEMBL26100535 | 0.74 | PTGS2 (0.37) | MAPK14ADKPTGS2 | |
| SCHEMBL14519679 | 0.73 | JAK3 (0.41) | MAPK14JAK2JAK3MAPK13MAPK12 | |
| SCHEMBL26103887 | 0.73 | KIT (0.39) | MAPK14JAK2JAK3EGFR | |
| SCHEMBL28329372 | 0.72 | ADORA1 (0.49) | MAPK14ADORA1MAPK13GCGRMAPK12 | |
| SCHEMBL26102662 | 0.72 | KIT (0.37) | MAPK14 | |
| SCHEMBL26103471 | 0.72 | KIT (0.38) | MAPK14JAK2JAK3EGFR | |
| SCHEMBL652979 | 0.69 | NPC1 (0.44) | MAPK14ADKUSP1USP19UCHL3 | |
| SCHEMBL30362002 | 0.67 | ADORA1 (0.38) | MAPK14USP1ADORA1EGFRCYP1A2 | |
| SCHEMBL7856946 | 0.67 | TGFBR1 (0.51) | MAPK14CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023076849-A1 | INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR | ORIC PHARMACEUTICALS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |
| WO-2023076849-A1 | INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR | ORIC PHARMACEUTICALS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |