Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 6/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.32 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.32 |
| ▸ | CFTR | P13569 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 2/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | PDE1A | P54750 | 1/20 | 0.30 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.30 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30298010 | 1.00 | NR3C1 (0.35) | NR3C1PIK3CDPIK3CAPIK3CGCSNK1A1 | |
| SCHEMBL21631562 | 0.77 | YTHDC1 (0.40) | RET | |
| SCHEMBL30297955 | 0.73 | PLK4 (0.50) | — | |
| SCHEMBL26505011 | 0.73 | PLK4 (0.50) | — | |
| SCHEMBL31194647 | 0.71 | KDM4E (0.47) | NR3C1CFTR | |
| SCHEMBL15353927 | 0.71 | CNR2 (0.37) | PIK3CAPIK3CGPDE4DPDE1APDE1B | |
| SCHEMBL173599 | 0.70 | PDE1C (0.50) | PDE4DPDE1APDE1BPDE1C | |
| SCHEMBL31194579 | 0.69 | KDM4E (0.55) | NR3C1PIK3CDPIK3CAPIK3CGCFTR | |
| SCHEMBL31194609 | 0.69 | KDM4E (0.51) | NR3C1PIK3CDPIK3CAPIK3CGCFTR | |
| SCHEMBL31194551 | 0.68 | ALDH1A1 (0.57) | NR3C1CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116023380-B | Pyrazolopyrimidine derivative, and preparation method and application thereof | 沈阳药科大学 | 2024-01-23 | — | — | CN | disclosed |
| WO-2023071218-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 沈阳药科大学 | 2023-05-04 | — | — | WO | disclosed |
| WO-2023071218-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 沈阳药科大学 | 2023-05-04 | — | — | WO | disclosed |
| CN-116023380-A | Pyrazolopyrimidine derivative, and preparation method and application thereof | 沈阳药科大学 | 2023-04-28 | — | — | CN | disclosed |