Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 3/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.39 |
| ▸ | ITGAL | P20701 | 3/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 7/20 | 0.38 |
| ▸ | ITGAV | P06756 | 7/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 3/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.37 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.37 |
| ▸ | ITGB8 | P26012 | 2/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.37 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.37 |
| ▸ | GRN | P28799 | 1/20 | 0.37 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23978807 | 1.00 | ITGB2 (0.39) | ITGB2ICAM1ITGALITGB1ITGAV | |
| SCHEMBL21358871 | 0.85 | ITGB1 (0.48) | ITGB2ICAM1ITGALITGB1ITGAV | |
| SCHEMBL21358869 | 0.85 | ITGB1 (0.48) | ITGB2ICAM1ITGALITGB1ITGAV | |
| SCHEMBL23978613 | 0.85 | AAK1 (0.37) | SYKAAK1KDM4EIDO1 | |
| SCHEMBL26107081 | 0.83 | PPARG (0.39) | ITGB2ICAM1ITGALITGB1ITGAV | |
| SCHEMBL26107077 | 0.83 | PPARG (0.39) | ITGB2ICAM1ITGALITGB1ITGAV | |
| SCHEMBL23978757 | 0.79 | ITGB1 (0.51) | ITGB2ICAM1ITGALITGB1ITGAV | |
| SCHEMBL23978812 | 0.76 | CTSL (0.45) | ITGB2ICAM1ITGALITGB1ITGAV | |
| SCHEMBL30279367 | 0.76 | CTSL (0.45) | ITGB2ICAM1ITGALITGB1ITGAV | |
| SCHEMBL26103779 | 0.76 | CTSL (0.45) | ITGB2ICAM1ITGALITGB1ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11643388-B2 | Inhibitors of alpha 2 beta 1 integrin and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2023-05-09 | — | — | US | disclosed |
| CN-115916176-A | Inhibitors of alpha 2 beta 1 integrin and methods of use thereof | 加利福尼亚大学董事会 | 2023-04-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11643388-B2 | Inhibitors of alpha 2 beta 1 integrin and methods of use thereof | ITGB1, ITGB2, ITGA2 | ITGB2 2/4885ICAM1 21/4885ITGAL 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.