Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 1/20 | 0.47 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 13/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 9/20 | 0.40 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27233778 | 0.89 | CDK12 (0.56) | CCNKCDK12PTGDR2HCRTR1TIPARP | |
| SCHEMBL27233705 | 0.89 | CDK12 (0.56) | CCNKCDK12PTGDR2HCRTR1TIPARP | |
| SCHEMBL27233710 | 0.89 | CDK12 (0.56) | CCNKCDK12PTGDR2HCRTR1TIPARP | |
| SCHEMBL17729543 | 0.83 | CCR6 (0.50) | HCRTR1LMNAMAPTHTTSMN1; SMN2 | |
| SCHEMBL26126417 | 0.81 | MAPT (0.45) | CCNKCDK12HCRTR1EGFRTIPARP | |
| SCHEMBL31581713 | 0.79 | HCRTR1 (0.45) | CCNKCDK12PTGDR2HCRTR1HCRTR2 | |
| SCHEMBL28214824 | 0.78 | GAA (0.47) | HTT | |
| SCHEMBL25226590 | 0.78 | MAPK3 (0.50) | CCNKCDK12HCRTR1HCRTR2TIPARP | |
| SCHEMBL30397933 | 0.78 | PTGDR2 (0.42) | CCNKCDK12PTGDR2HCRTR1HCRTR2 | |
| SCHEMBL21722966 | 0.76 | EPHX2 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192989-A2 | PHTHALAZINONE COMPOUNDS AS PARP7 INHIBITORS | AZKARRA THERAPEUTICS, INC. (US) | 2023-10-05 | — | — | WO | disclosed |