Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.37 |
| ▸ | HTR2A | P28223 | 6/20 | 0.37 |
| ▸ | DRD5 | P21918 | 4/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29654713 | 0.86 | HTR2C (0.45) | HTR2CHTR2ANPC1RAB9ATP53 | |
| SCHEMBL515378 | 0.86 | HTR2C (0.45) | HTR2CHTR2ANPC1RAB9ATP53 | |
| SCHEMBL18840154 | 0.82 | HTR2A (0.38) | HTR2CHTR2ANPC1RAB9ATP53 | |
| SCHEMBL1813477 | 0.81 | KDM1A (0.40) | KDM1A | |
| SCHEMBL24746334 | 0.81 | HTR2C (0.41) | HTR2CHTR2AHTR2BNPC1RAB9A | |
| SCHEMBL30630193 | 0.81 | HTR2C (0.41) | HTR2CHTR2AHTR2BNPC1RAB9A | |
| SCHEMBL6711039 | 0.78 | HTR2C (0.56) | HTR2CHTR2AHTR2BNPC1RAB9A | |
| SCHEMBL17258826 | 0.78 | HTR2A (0.44) | HTR2CHTR2ADRD5KDM1A | |
| SCHEMBL2960423 | 0.77 | LMNA (0.40) | HTR2CHTR2ATP53KDM4EALDH1A1 | |
| SCHEMBL26120924 | 0.77 | CYP11B1 (0.38) | HTR2CHTR2ADRD5HTR2BNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192989-A2 | PHTHALAZINONE COMPOUNDS AS PARP7 INHIBITORS | AZKARRA THERAPEUTICS, INC. (US) | 2023-10-05 | — | — | WO | disclosed |
| WO-2023192989-A2 | PHTHALAZINONE COMPOUNDS AS PARP7 INHIBITORS | AZKARRA THERAPEUTICS, INC. (US) | 2023-10-05 | — | — | WO | disclosed |