Sugi Predict

Sugi Predict / Compounds / SCHEMBL515378

SCHEMBL515378

SCHEMBL515378

COc1cc(Br)c(C2OCCO2)cc1OC

nearest known ligand 0.48

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ HTR2C P28335 5/20 0.45
▸ HTR2A P28223 4/20 0.45
▸ TP53 P04637 1/20 0.43
▸ PRKDC P78527 1/20 0.39
▸ POLB P06746 1/20 0.38
▸ L3MBTL1 Q9Y468 1/20 0.38
▸ LCK P06239 1/20 0.38
▸ FYN P06241 1/20 0.38
▸ NPC1 O15118 1/20 0.38
▸ RAB9A P51151 1/20 0.38
▸ CYP3A4 P08684 1/20 0.37
▸ MAPT P10636 1/20 0.36
▸ NPSR1 Q6W5P4 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29654713 1.00 HTR2C (0.45) HTR2CHTR2ATP53PRKDCPOLB
SCHEMBL2960423 0.89 LMNA (0.40) HTR2CHTR2ATP53POLBMAPT
SCHEMBL18840154 0.88 HTR2A (0.38) HTR2CHTR2ATP53NPC1RAB9A
SCHEMBL6711039 0.87 HTR2C (0.56) HTR2CHTR2APOLBL3MBTL1NPC1
SCHEMBL26122002 0.86 HTR2C (0.37) HTR2CHTR2ATP53NPC1RAB9A
SCHEMBL5883357 0.83 HTR2A (0.41) HTR2CHTR2ATP53PRKDCPOLB
SCHEMBL6040717 0.80 HTR2C (0.47) HTR2CHTR2ANPC1RAB9ACYP3A4
SCHEMBL24746334 0.80 HTR2C (0.41) HTR2CHTR2APOLBL3MBTL1NPC1
SCHEMBL30630193 0.80 HTR2C (0.41) HTR2CHTR2APOLBL3MBTL1NPC1
SCHEMBL20263723 0.80 NPC1 (0.32) NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12459930-B2 Compounds for the inhibition of unregulated cell growth GODAVARI BIOREFINERIES LIMITED (IN) 2025-11-04 — — US disclosed
US-12337007-B2 Patentiflorin A analogs as antiviral agents HONG KONG BAPTIST UNIVERSITY (CN) 2025-06-24 — — US disclosed
US-20230248754-A1 Patentiflorin A Analogs as Antiviral Agents HONG KONG BAPTIST UNIVERSITY (CN) 2023-08-10 — — US disclosed
US-11680078-B2 Anticancer compounds GODAVARI BIOREFINERIES LTD. (IN) 2023-06-20 — — US disclosed
US-11680078-B2 Anticancer compounds GODAVARI BIOREFINERIES LTD. (IN) 2023-06-20 — — US disclosed
US-11638713-B2 Patentiflorin A analogs as antiviral agents HONG KONG BAPTIST UNIVERSITY (CN) 2023-05-02 — — US disclosed
US-20220389046-A1 ANTICANCER COMPOUNDS GODAVARI BIOREFINERIES LIMITED 2022-12-08 — — US disclosed
WO-2022135136-A1 TUBERCULATIN ANALOGS AS ANTIVIRAL AGENTS HONG KONG BAPTIST UNIVERSITY (CN) 2022-06-30 — — WO disclosed
CN-114555077-A Patentiflorin A analogs as antiviral agents 香港浸会大学 2022-05-27 — — CN disclosed
US-20220073501-A1 COMPOUNDS FOR THE INHIBITION OF UNREGULATED CELL GROWTH GODAVARI BIOREFINERIES LIMITED (IN) 2022-03-10 — — US disclosed
US-5874460-A ADMINISTERING TO LOWER INTRAOCCULAR PRESSURE IN THE EYE OF A MAMMAL ALLERGAN SALES INC. (US) 1999-02-23 — — US disclosed
US-5814657-A 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents ALLERGAN (US) 1998-09-29 — — US disclosed
US-5808101-A 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents ALLERGAN (US) 1998-09-15 — — US disclosed
US-5714621-A 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents ALLERGAN (US) 1998-02-03 — — US disclosed
US-5710288-A 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents ALLERGAN (US) 1998-01-20 — — US disclosed
US-5654329-A 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents ALLERGAN (US) 1997-08-05 — — US disclosed
US-5523296-A TREATING EYE HYPERTENSIVE CONDITION AFTER SURGERY, GLAUCOMA; SIDE EFFECT REDUCTION ALLERGAN, INC. (US) 1996-06-04 — — US disclosed
EP-0695300-A1 NOVEL 1,3-BENZODIOXOLE AND 1,2-DIALKOXYBENZENE DERIVATIVES AS OCULAR HYPOTENSIVE AGENTS ALLERGAN, INC. (US) 1996-02-07 — — EP disclosed
US-5369127-A Treatment of glaucoma ALLERGAN, INC. (US) 1994-11-29 — — US disclosed
WO-1994024121-A1 NOVEL 1,3-BENZODIOXOLE AND 1,2-DIALKOXYBENZENE DERIVATIVES AS OCULAR HYPOTENSIVE AGENTS ALLERGAN, INC. (US) 1994-10-27 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230248754-A1 Patentiflorin A Analogs as Antiviral Agents MAVS, MIF, SARS1 HTR2C 4125/4885HTR2A 3199/4885TP53 1118/4885
US-11638713-B2 Patentiflorin A analogs as antiviral agents MAVS, MIF, SARS1 HTR2C 4125/4885HTR2A 3199/4885TP53 1118/4885
US-11680078-B2 Anticancer compounds MKI67, CCNI, API5 HTR2C 4477/4885HTR2A 4772/4885TP53 65/4885
US-12337007-B2 Patentiflorin A analogs as antiviral agents MAVS, MIF, SARS1 HTR2C 4125/4885HTR2A 3199/4885TP53 1118/4885
US-12459930-B2 Compounds for the inhibition of unregulated cell growth MKI67, CCNI, CCNA2 HTR2C 3682/4885HTR2A 4006/4885TP53 179/4885
US-20220389046-A1 ANTICANCER COMPOUNDS MKI67, CCNI, API5 HTR2C 4477/4885HTR2A 4772/4885TP53 65/4885
US-20220073501-A1 COMPOUNDS FOR THE INHIBITION OF UNREGULATED CELL GROWTH MKI67, CCNI, CCNA2 HTR2C 3682/4885HTR2A 4006/4885TP53 179/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.