SCHEMBL26123700

SCHEMBL26123700

COc1ccc(C(O[C@H]2C(F)(F)[C@H](n3ccc(N)nc3=O)O[C@]2(C)CO[Si](C)(C)C(C)(C)C)(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.37

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PDE4D Q08499 1/20 0.37
PDE3A Q14432 1/20 0.37
SLC29A1 Q99808 1/20 0.37
POLA1 P09884 2/20 0.34
TYMP P19971 1/20 0.30
KIF11 P52732 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25402578 0.89 PDE4D (0.35) PDE4DPDE3ASLC29A1POLA1
SCHEMBL26120946 0.85 DUT (0.40) TYMP
SCHEMBL17384712 0.84 PDE4D (0.34) PDE4DPDE3ASLC29A1POLA1
SCHEMBL25401458 0.79 CACNA1F (0.31) PDE3A
SCHEMBL25398163 0.76 ALDH1A1 (0.30)
SCHEMBL25400032 0.74 DUT (0.38)
SCHEMBL26127108 0.74 DUT (0.38)
SCHEMBL4074704 0.73 TYMP (0.33) TYMP
SCHEMBL16144282 0.73 PDE4D (0.34) PDE4DPDE3ASLC29A1POLA1TYMP
SCHEMBL16144281 0.72 PDE3A (0.36) PDE4DPDE3ASLC29A1POLA1TYMP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250215039-A1 NUCLEOSIDES FOR TREATING CANCER PRIMEFOUR THERAPEUTICS INC (US) 2025-07-03 US disclosed
WO-2023192499-A1 NUCLEOSIDES FOR TREATING CANCER PRIMEFOUR THERAPEUTICS, INC. (US) 2023-10-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250215039-A1 NUCLEOSIDES FOR TREATING CANCER UNG, OGG1, NTPCR PDE4D 1651/4885PDE3A 1349/4885SLC29A1 94/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.