SCHEMBL26123717

SCHEMBL26123717

Nc1cnn(-c2ccccn2)c1C(F)(F)F

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
OXTR P30559 3/20 0.42
AVPR1A P37288 1/20 0.42
IRAK4 Q9NWZ3 3/20 0.42
RAB9A P51151 2/20 0.41
NPC1 O15118 1/20 0.41
TP53 P04637 1/20 0.41
HPGD P15428 1/20 0.41
CYP17A1 P05093 2/20 0.40
MAPT P10636 2/20 0.38
POLB P06746 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
KDM4E B2RXH2 2/20 0.36
HTT P42858 1/20 0.36
ALDH1A1 P00352 1/20 0.36
CYP1A2 P05177 1/20 0.36
FLT3 P36888 3/20 0.35
AURKA O14965 2/20 0.35
MAP4K4 O95819 2/20 0.35
PIM1 P11309 2/20 0.35
PRKACA P17612 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL26126644 0.98 OXTR (0.41) OXTRAVPR1AIRAK4RAB9ANPC1
SCHEMBL26127920 0.80 SMPD3 (0.37) OXTRRAB9ANPC1HPGDCYP17A1
Hydrochloric Acid SCHEMBL30546623 0.79 HSP90AA1 (0.34) RAB9ANPC1CYP17A1MAPTPOLB
Hydrochloric Acid SCHEMBL26127628 0.79 CYP17A1 (0.36) CYP17A1MAPTPOLBSMN1; SMN2KDM4E
Hydrochloric Acid SCHEMBL26121110 0.79 HSP90AA1 (0.34) RAB9ANPC1CYP17A1MAPTPOLB
SCHEMBL30147333 0.79 MAPT (0.51) RAB9ANPC1TP53HPGDMAPT
SCHEMBL3252316 0.78 RAB9A (0.52) IRAK4RAB9ANPC1TP53HPGD
Hydrochloric Acid SCHEMBL30546499 0.78 CYP17A1 (0.34) CYP17A1MAPTKDM4ECYP1A2SCN9A
Hydrochloric Acid SCHEMBL26126624 0.78 CYP17A1 (0.34) CYP17A1MAPTKDM4ECYP1A2SCN9A
Hydrochloric Acid SCHEMBL6087752 0.77 RAB9A (0.51) IRAK4RAB9ANPC1TP53HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4707276-A2 MALT1 MODULATORS AND USES THEREOF Rarefied Biosciences, Inc. (US) 2026-03-11 EP disclosed
EP-4499611-B1 MALT1 MODULATORS AND USES THEREOF RAREFIED BIOSCIENCES INC (US) 2026-02-18 EP disclosed
EP-4673150-A2 COMPOSITIONS AND METHODS FOR TREATING MALT1 ASSOCIATED DISEASES Rarefied Biosciences, Inc. (US) 2026-01-07 EP disclosed
US-20250326738-A1 MALT1 Modulators and Uses Thereof RAREFIED BIOSCIENCES, INC. (US) 2025-10-23 US disclosed
EP-4499611-A1 MALT1 MODULATORS AND USES THEREOF Rarefied Biosciences, Inc. (US) 2025-02-05 EP disclosed
CN-119032083-A MALT1 modulators and uses thereof 稀有生物科学股份有限公司 2024-11-26 CN disclosed
WO-2024182599-A2 COMPOSITIONS AND METHODS FOR TREATING MALT1 ASSOCIATED DISEASES RAREFIED BIOSCIENCES, INC. (US) 2024-09-06 WO disclosed
WO-2023192506-A1 MALT1 MODULATORS AND USES THEREOF RARIFIED BIOSCIENCES, INC. (US) 2023-10-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250326738-A1 MALT1 Modulators and Uses Thereof MALT1, SQSTM1, PPP1R10 OXTR 4832/4885AVPR1A 4816/4885IRAK4 784/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.