Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.69 |
| ▸ | EGFR known ✓ | P00533 | 1/20 | 0.61 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.55 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 14/20 | 0.69 |
| ▸ | RET | P07949 | 7/20 | 0.69 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.69 |
| ▸ | FLT1 | P17948 | 5/20 | 0.69 |
| ▸ | FLT4 | P35916 | 5/20 | 0.69 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.69 |
| ▸ | KIT | P10721 | 4/20 | 0.69 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.69 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.69 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.69 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.69 |
| ▸ | STK10 | O94804 | 2/20 | 0.69 |
| ▸ | ABL1 | P00519 | 2/20 | 0.69 |
| ▸ | BCR | P11274 | 2/20 | 0.69 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.69 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL31055823 | 1.00 | KDR (0.69) | KDRRETPDGFRAFLT1FLT4 | |
| Maleic Acid SCHEMBL26124672 | 1.00 | KDR (0.69) | KDRRETPDGFRAFLT1FLT4 | |
| SCHEMBL863736 | 0.95 | KDR (0.76) | KDRRETPDGFRAFLT1FLT4 | |
| SCHEMBL31055824 | 0.95 | KDR (0.76) | KDRRETPDGFRAFLT1FLT4 | |
| SCHEMBL26127786 | 0.92 | KDR (0.71) | KDRRETPDGFRAFLT1FLT4 | |
| SCHEMBL31231426 | 0.92 | KDR (0.71) | KDRRETPDGFRAFLT1FLT4 | |
| SCHEMBL1893312 | 0.89 | KDR (0.64) | KDRRETPDGFRAFLT1FLT4 | |
| SCHEMBL864748 | 0.89 | KDR (0.73) | KDRRETPDGFRAFLT1FLT4 | |
| SCHEMBL23366513 | 0.88 | KDR (0.83) | KDRRETPDGFRAFLT1FLT4 | |
| SCHEMBL1893120 | 0.88 | KDR (0.64) | KDRRETPDGFRAFLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023190709-A1 | LIPOSOME COMPOSITION AND LIPOSOME-CONTAINING PHARMACEUTICAL COMPOSITION | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 2023-10-05 | — | — | WO | disclosed |