SCHEMBL26128286

SCHEMBL26128286

CC(C)Cc1cc(-c2ccc(Cn3ccnc3C(C)C)c(C#N)c2)c(S(=O)(=O)NC(C)(C)C)s1

nearest known ligand 0.48

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR2 P50052 20/20 0.48
CYP3A4 P08684 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26129093 0.91 AGTR2 (0.51) AGTR2CYP3A4
SCHEMBL26127611 0.91 AGTR2 (0.55) AGTR2CYP3A4
SCHEMBL26129333 0.90 AGTR2 (0.46) AGTR2CYP3A4
SCHEMBL30613499 0.89 AGTR2 (0.43) AGTR2CYP3A4
SCHEMBL26126548 0.89 AGTR2 (0.43) AGTR2CYP3A4
SCHEMBL25246111 0.88 AGTR2 (0.47) AGTR2CYP3A4
SCHEMBL31476809 0.87 AGTR2 (0.56) AGTR2CYP3A4
SCHEMBL26129202 0.87 AGTR2 (0.56) AGTR2CYP3A4
SCHEMBL26129204 0.86 AGTR2 (0.48) AGTR2CYP3A4
SCHEMBL26129143 0.84 AGTR2 (0.56) AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250214978-A1 AT2R AGONIST Wuhan Humanwell Innovative Drug Research and Development Center Limited Company (CN) 2025-07-03 US disclosed
EP-4506345-A1 AT2R AGONIST Wuhan Humanwell Innovative Drug Research and Development Center Limited Company (CN) 2025-02-12 EP disclosed
CN-116891464-A AT2R agonist 武汉人福创新药物研发中心有限公司 2023-10-17 CN disclosed
WO-2023193733-A1 AT2R AGONIST 武汉人福创新药物研发中心有限公司 2023-10-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250214978-A1 AT2R AGONIST AGTR1, AGTR2, AVPR2 AGTR2 2/4885CYP3A4 1748/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.