Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 6/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA6 | P23280 | 1/20 | 0.32 |
| ▸ | CA5A | P35218 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26405752 | 0.81 | LMNA (0.44) | CFTRAR | |
| SCHEMBL26128015 | 0.80 | ERN1 (0.37) | ERN1HDAC1HDAC6ALDH1A1CYP2C19 | |
| SCHEMBL27615838 | 0.78 | CFTR (0.35) | CFTRHDAC1ALDH1A1HDAC2MAOB | |
| SCHEMBL26131350 | 0.77 | ALDH1A1 (0.42) | ERN1ALDH1A1TSHRCYP1A2CYP2C19 | |
| SCHEMBL31422943 | 0.73 | KIF11 (0.43) | CFTRERN1TSHRCA12CA1 | |
| SCHEMBL17336740 | 0.73 | CFTR (0.41) | CFTRALDH1A1TSHRHDAC2CA12 | |
| SCHEMBL22637106 | 0.73 | HDAC1 (0.39) | CFTRHDAC1ALDH1A1HDAC2CA12 | |
| SCHEMBL26131564 | 0.73 | KDM4E (0.43) | ERN1ALDH1A1TSHRKDM4E | |
| SCHEMBL22636593 | 0.72 | KDR (0.44) | CFTRHDAC1HDAC8HDAC6ALDH1A1 | |
| SCHEMBL4957900 | 0.71 | POLB (0.48) | ALDH1A1TSHRCYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024082055-A1 | ANTIBODY-DRUG CONJUGATES TARGETING NAPI2B AND METHODS OF USE | ZYMEWORKS BC INC. (CA) | 2024-04-25 | — | — | WO | disclosed |
| WO-2024082051-A1 | ANTIBODY-DRUG CONJUGATES TARGETING GLYPICAN-3 AND METHODS OF USE | ZYMEWORKS BC INC. (CA) | 2024-04-25 | — | — | WO | disclosed |
| EP-4347601-A1 | CAMPTOTHECIN ANALOGUES, CONJUGATES AND METHODS OF USE | Zymeworks BC Inc. (CA) | 2024-04-10 | — | — | EP | disclosed |
| WO-2023178452-A1 | ANTIBODY-DRUG CONJUGATES TARGETING FOLATE RECEPTOR ALPHA AND METHODS OF USE | ZYMEWORKS BC INC. (CA) | 2023-09-28 | — | — | WO | disclosed |